Cyclization and antimicrobial evolution of 1,3,4-oxadiazoles by carbohydrazide

A series of dihydropyrimidine substituted 1,3,4-oxadiazole derivatives was synthesized by cyclization of carbohydrazide by phosphoryl chloride and benzoic acid in acidic condition. The structures were perceived on the establishment of spectral tools and their purity by elemental analysis. Every compound was primary assessed for their in vitro antimicrobial activities against 5 bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and 2 fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans var. grubii (H99; ATCC 208821)]. Some compounds displayed significant antimicrobial activity, out of 15 compounds, 11 compounds indicated promising antifungal activities without any indications of human cells cytotoxic [Hk: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [RBC (ARCBS 5400 00150)].