Chenodeoxycholic acid: A Physicochemical study

Some physicochemical properties such as dissociation constant, acoustical parameters and thermal studies of acid are studied in methanol and 1,4-dioxane at 298.15 K. The dissociation constant of Chenodeoxycholic acid is evaluated in binary mixtures (of methanol / 1,4-dioxane + water) by two methods; half-integral and average methods. The acoustical properties have been evaluated from experimental data of density, viscosity and ultrasonic velocity. It is observed that in both the solvents, strong solute-solvent interactions exist. Thermal degradation of Chenodeoxycholic acid is found to be a single step process.